ULTRASENSITIVE DETECTION OF LIPOARABINOMANNAN WITH PLASMONIC GRATING BIOSENSORS IN CLINICAL SAMPLES OF HIV NEGATIVE PATIENTS WITH TUBERCULOSIS.

Ultrasensitive detection of lipoarabinomannan with plasmonic grating biosensors in clinical samples of HIV negative patients with tuberculosis.

BACKGROUND:Timely diagnosis of tuberculosis disease is critical for positive patient outcomes, yet potentially millions go undiagnosed or unreported each year.Sputum is widely used as the testing input, but limited by its complexity, heterogeneity, and sourcing problems.Finding methods to interrogate noninvasive, non-sputum clinical specimens is in

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Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade

Abstract Dietary methionine interventions are beneficial to apoptosis-inducing chemotherapy and radiotherapy for cancer, while their effects on ferroptosis-targeting therapy and immunotherapy are unknown.Here we show the length of time methionine deprivation affects tumoral ferroptosis differently.Prolonged methionine deprivation prevents glutathio

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96 Disparities in healthcare discrimination among sexual minority groups: Insights from the NIH All of Us Program

Objectives/Goals: Discriminatory experiences within healthcare settings significantly hinder equitable health access for sexual minority groups (SMPs) in the USA.These discriminatory experiences can manifest in various forms (e.g., refusal of care).We aimed to explore different types of discrimination encountered by SMPs in the healthcare settings.

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